The changes to Janine only applied to the ABC episodes, so in all other licensing (ie the action figures, the Now comic book) her original appearance and attitude remained intact. When the changes failed, the producers asked Stracynski to return to the program; he was too busy to do so, but did contribute a few more scripts, most notably "Janine, You've Changed", which explained the changes in-continuity as the work of a "Makeoverus Lotsabucks" posing as her "Fairy Godmother"
Venkman's voice was changed, according to movie and Real Ghostbusters producer Michael C. Gross, because Bill Murray complained that the cartoon voice (Lorenzo Music) didn't sound enough like him (even though Real Ghostbuster Peter Venkman didn't look like him at all)
This information came interview posted on [[Ghostbusters HQ: http://web.archive.org/web/20041216191647/http://www.ghostbustershq.com/interviews/interviewmichael.php
Presumably, Venkman's attitude toward Slimer was changed by the same "experts" that ordered Janine's mental lobotomy... unlike Janine, the changes to Venkman were never noted or addressed within the continuity of the show itself.
Arsenio Hall resigned as Winston's voice after the 1987-1988 season, because he was in the process of starting a talk show that began in fall 1988 and ran for several years. Most fans consider his replacement, Buster Jones, as by far the least noticeable and unpleasant change.